Dennis Discher
Latest
- Challenges and opportunities for the next generation of cardiovascular tissue engineering
- Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate
- Tension in fibrils suppresses their enzymatic degradation - A molecular mechanism for use it or lose it
- Mechanosensing by the lamina protects against nuclear Rupture, DNA Damage, and cell-cycle Arrest
- Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure
- Nuclear mechanosensing
- Nuclear rupture at sites of high curvature compromises retention of DNA repair factors
- Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A, C in iPS-derived mesenchymal stem cells
- Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics
- Mechanosensing of matrix by stem cells: From matrix heterogeneity, contractility, and the nucleus in pore-migration to cardiogenesis and muscle stem cells in vivo
- SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors
- Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation
- Matrix Mechanosensing: From Scaling Concepts in Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer
- Mechanosensing by the nucleus: From pathways to scaling relationships
- Mechanical signaling coordinates the embryonic heartbeat
- Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor
- Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin