Publications

Sangkyun Cho, Siyeon Rhee, Christopher Madl, Arianne Caudal, Dilip Thomas, Hyeonyu Kim, Ana Kojic, Hye Sook Shin, Abhay Mahajan, James Jahng, Xi Wang, Phung Thai, David Paik, Mingqiang Wang, McKay Mullen, Natalie Baker, Jeremy Leitz, Souhrid Mukherjee, Virginia Winn, Y Joseph Woo, Helen Blau, Joseph Wu. Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis. Nature, 2025.
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Sangkyun Cho, Dennis Discher, Kam Leong, Gordana Vunjak-Novakovic, Joseph Wu. Challenges and opportunities for the next generation of cardiovascular tissue engineering. Nat Methods, 2022.
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Charlotte Pfeifer, Michael Tobin, Sangkyun Cho, Manasvita Vashisth, Lawrence Dooling, Lizbeth Vazquez, Emma Ricci De Lucca, Keiann Simon, Dennis Discher. Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate. Nucleus, 2022.
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Chelsea Lee, Sangkyun Cho, Celine Lai, Sushma Shenoy, Randall Vagelos, Joseph Wu. Generation of three iPSC lines from dilated cardiomyopathy patients carrying a pathogenic LMNA variant. Stem Cell Res, 2022.
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Sangkyun Cho, Chelsea Lee, Celine Lai, Yan Zhuge, Francois Haddad, Michael Fowler, Karim Sallam, Joseph Wu. Heterozygous LMNA mutation-carrying iPSC lines from three cardiac laminopathy patients. Stem Cell Res, 2022.
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Manasvita Vashisth, Sangkyun Cho, Jerome Irianto, Yuntao Xia, Mai Wang, Brandon Hayes, Daniel Wieland, Rebecca Wells, Farshid Jafarpour, Andrea Liu, Joseph Wu. Scaling concepts in omics - Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis. PNAS, 2021.
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Sangkyun Cho, Chelsea Lee, Mark Skylar-Scott, Sarah Heilshorn, Joseph Wu. Reconstructing the heart using iPSCs: Engineering strategies and applications. J Cell Mol Cardiol, 2021.
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Sangkyun Cho, David Paik, Joseph Wu. An extracellular matrix paradox in myocardial scar formation. Sig Trans Target Ther, 2020.
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David Parik, Sangkyun Cho, Lei Tian, Howard Chang, Joseph Wu. Single-cell RNA sequencing in cardiovascular development, disease and medicine. Nat Rev Cardiol, 2020.
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Karanvir Saini, Sangkyun Cho, Lawrence Dooling, Dennis Discher. Tension in fibrils suppresses their enzymatic degradation - A molecular mechanism for use it or lose it. Matrix Biol, 2020.
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Sangkyun Cho, Manasvita Vashisth, Amal Abbas, Stephanie Majkut, Kenneth Vogel, Yuntao Xia, Irena L Ivanovska, Jerome Irianto, Manorama Tewari, Kuangzheng Zhu, Elisia D Tichy, Foteini Mourkioti, Hsin-Yao Tang, Roger a Greenberg, Benjamin L Prosser, Dennis Discher. Mechanosensing by the lamina protects against nuclear Rupture, DNA Damage, and cell-cycle Arrest. Dev Cell, 2019.
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Xia, Sangkyun Cho, Manasvita Vashisth, Irena Ivanovska, Dave Dingal, Dennis Discher. Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure. Methods, 2019.
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Yuntao Xia, Charlotte Pfeifer, Sangkyun Cho, Dennis Discher, Jerome Irianto. Nuclear mechanosensing. Emerg Top Life Sci, 2018.
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Yuntao Xia, Irena Ivanovska, Kuangzheng Zhu, Lucas Smith, Jerome Irianto, Charlotte Pfeifer, Cory Alvey, Jiazheng Ji, Dazhen Liu, Sangkyun Cho, Rachel Bennett, Andrea Liu, Roger Greenberg, Dennis Discher. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J Cell Biol, 2018.
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Lucas R Smith, Sangkyun Cho, Dennis Discher. Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics. Physiology, 2018.
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Sangkyun Cho, Amal Abbas, Jerome Irianto, Irena Ivanovska, Yuntao Xia, Manu Tewari, Dennis Discher. Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A, C in iPS-derived mesenchymal stem cells. Nucleus, 2018.
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Lucas R Smith, Sangkyun Cho, Dennis Discher. Mechanosensing of matrix by stem cells: From matrix heterogeneity, contractility, and the nucleus in pore-migration to cardiogenesis and muscle stem cells in vivo. Semin Cell Dev Biol, 2017.
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Corey Alvey, Kyle Spinler, Jerome Irianto, Charlotte Pfeifer, Brandon Hayes, Yuntao Xia, Sangkyun Cho, Dave Dingal, Jake Hsu, Lucas Smith, Manu Tewari, Dennis Discher. SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors. Curr Biol, 2017.
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Irena Ivanovska, Joe Swift, Kyle Spinler, Dave Dingal, Sangkyun Cho, Dennis Discher. Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation. Mol Biol Cell, 2017.
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Dennis Discher, Lucas Smith, Sangkyun Cho, Mark Colasurdo, Andres Garcia, Sam Safran. Matrix Mechanosensing: From Scaling Concepts in Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer. Annu Rev Biophys, 2017.
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Sangkyun Cho, Jerome Irianto, Dennis Discher. Mechanosensing by the nucleus: From pathways to scaling relationships. J Cell Biol, 2017.
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Kevin Chiou, Jason Rocks, Christina Chen, Sangkyun Cho, Koen Merkus, Anjali Rajaratnam, Patrick Robinson, Manu Tewari, Kenneth Vogel, Stephanie Majkut, Benjamin Prosser, Dennis Discher, Andrea Liu. Mechanical signaling coordinates the embryonic heartbeat. PNAS, 2016.
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Dave Dingal, Andrew Bradshaw, Sangkyun Cho, Matthew Raab, Amnon Buxboim, Joe Swift, Dennis Discher. Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor. Nat Mater, 2015.
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Amnon Buxboim, Joe Swift, Jerome Irianto, Kyle Spinler, PCP Dave Dingal, Avathamsa Athirasala, Yun-Ruei Kao, Sangkyun Cho, Takamasa Harada, Jae-Won Shin, Dennis Discher. Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin. Curr Biol, 2014.
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Dong-Hwee Kim, Sangkyun Cho, Denis Wirtz. Tight coupling between nucleus and cell migration through the perinuclear actin cap. J Cell Sci, 2014.
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